Diclofenac and Celecoxib inhibit T3

Caution, if you take either of these common Non-Steroidal Anti-Inflammatory (NSAID) drugs and have Thyroid T3-hormone issues, or problems in your blood vessels!

In my recent research I found a 2016 article with this title: “Evidence that diclofenac and celecoxib are thyroid hormone receptor beta antagonists.” (Zloh, et al, 2016) http://www.ncbi.nlm.nih.gov/pubmed/26792060

They analyzed the molecular structure of these drugs to confirm their “TRβ antagonistic properties.” They also measured “changes to Triiodothyronine (T3) induced vasodilation of rat mesenteric arteries” with these drugs.

They found these two drugs “significantly inhibited T3 induced vasodilation compared to controls.”

Inhibition of vasodilation is obviously NOT the effect you want if you have atherosclerosis or any problems with blood vessel spasms or constriction.

I was recently put on Diclofenac to resolve my chest arthritis AND at the same time, I was starting T3 therapy to resolve chest pain from vasoconstriction. Obviously the combination of these two therapies was contradictory.

In contrast, they tested naproxen and it did not have this TRβ inhibitory effect.

References

Zloh, M., Perez-Diaz, N., Tang, L., & Patel, P. (2016). Evidence that diclofenac and celecoxib are thyroid hormone receptor beta antagonists. Life Sciences, 146, 66–72. http://doi.org/10.1016/j.lfs.2016.01.013

Aortitis in Ankylosing Spondylitis

This blog post features recent articles that may offer explanations of the connection between aortitis and Ankylosing Spondylitis.

It’s challenging for doctors and patients to understand what is going on when two conditions present together. Some doctors might attribute the arthritic pain to non-infectious costochondritis (“inflammation of the costal cartilage, the structure that connects each rib to the sternum at the costosternal joint” [Wikipedia: Costochondritis]) and not look further into the deeper vascular phenomena also associated with Ankylosing Spondylitis.

If the aorta is the problem and not the heart itself, will troponin levels be elevated? Not always, according to the case presented by Looi, et al (2011).

In some cases an ECG reveals a problem, and this at least will engage heart specialists.

But what about cases in which the aorta is inflamed in the thoracic or abdominal areas, not near the septum or aortic valve?  What about “periaortitis,” as described below by Palazzi, et al? Will the symptoms of periaortitis likely register as a possibility in the minds of emergency specialists or rheumatologists?

Continue reading “Aortitis in Ankylosing Spondylitis”

Vitamin B5 for Ankylosing Spondylitis and Iritis

B-vitamin-sm
Image adapted from E-codices on Flickr

Based on about 20 years of experience with self-treatment, I firmly believe that daily therapeutic doses (500mg/day) of Vitamin B5 (Pantothenic Acid, Calcium Pantothenate) have an overall protective/preventive effect on my Ankylosing Spondylitis and Iritis (acute anterior uveitis), and that its effects are felt over time, not immediately.

Below I describe my personal experimentation.

I conclude this post with information from research articles. Continue reading “Vitamin B5 for Ankylosing Spondylitis and Iritis”